Review Quality Rating: 9 (strong) - View Quality Assessment Citation: de Campos TF, Maher CG, Steffens D, Fuller JT, & Hancock MJ. (2018). Exercise programs may be effective in preventing a new episode of neck pain: A systematic review and meta-analysis. Journal of Physiotherapy, 64(3), 159-165. Abstract QUESTION: What is the effectiveness of interventions that aim to prevent a new episode of neck pain?DESIGN: Systematic review and meta-analysis of randomised, controlled trials.PARTICIPANTS: People without neck pain at study entry.INTERVENTION: Any intervention aiming to prevent a future episode of neck pain.OUTCOME MEASURES: New episode of neck pain.RESULTS: Five trials including a total of 3852 individuals met the inclusion criteria. The pooled results from two randomised, controlled trials (500 participants) found moderate-quality evidence that exercise reduces the risk of a new episode of neck pain (OR 0.32, 95% CI 0.12 to 0.86). One of the meta-analysed trials included some co-interventions with the exercise. There was low-quality evidence from three randomised, controlled trials (3352 participants) that ergonomic programs do not reduce the risk of a new neck pain episode (OR 1.00, 95% CI 0.74 to 1.35).CONCLUSION: This review found moderate-quality evidence supporting the effectiveness of an exercise program for reducing the risk of a new episode of neck pain. There is a need for high-quality randomised, controlled trials evaluating interventions to prevent new episodes of neck pain. Keywords: Adults (20-59 years), Behaviour Modification (e.g., provision of item/tool, incentives, goal setting), Education / Awareness & Skill Development / Training, Health Care Setting, Injury Prevention/Safety, Meta-analysis