The aim of this systematic review was to identify, characterize, and analyze the effectiveness of healthcare interventions for perinatal depression in socially disadvantaged women. Prominent biomedical databases were searched in April 2013. Sixteen articles assessing 15 interventions to decrease depressive symptoms in socially disadvantaged women were selected. Most interventions were carried out in the United States (n = 11) and targeted ethnic minorities (n = 9). Approximately half of the interventions (53%) were effective in decreasing depressive symptoms, observing that culturally adapted, interpersonal therapy interventions were the most effective. Eleven interventions were included in the meta-analysis that showed a statistically significant reduction in overall depressive symptoms (-0.44, 95% CI [-0.67, -0.22]). Meta-regression indicated that several characteristics increased the effectiveness of the interventions.