Review Quality Rating: 9 (strong) - View Quality Assessment Citation: Anthony K, Robinson K, Logan P, Gordon AL, Harwood RH, & Masud T. (2013). Chair-based exercises for frail older people: A systematic review. BioMed Research International, 2013(309506). Abstract INTRODUCTION: Frail older people are often unable to undertake high-intensity exercise programmes. Chair-based exercises (CBEs) are used as an alternative, for which health benefits are uncertain. OBJECTIVE: To examine the effects of CBE programmes for frail older people through a systematic review of existing literature. METHOD: A systematic search was performed for CBE-controlled trials in frail populations aged >=65 years published between 1990 and February 2011 in electronic databases. Quality was assessed using the Jadad method. RESULTS: The search identified 164 references: with 42 duplicates removed, 122 reviewed, 116 excluded, and 6 analysed. 26 outcome measures were reported measuring 3 domains: mobility and function, cardiorespiratory fitness, mental health. All studies were of low methodological quality (Jadad score <=2; possible range 0-5). Two studies showed no benefit, and four reported some evidence of benefit in all three domains. No harmful effects were reported; compliance was generally good. CONCLUSION: The quality of the evidence base for CBEs is low with inconclusive findings to clearly inform practice. A consensus is required on the definition and purpose of CBEs. Large well-designed randomised controlled trials to test the effectiveness of CBE are justified. Keywords: Behaviour Modification, Clinic, Health Through the Ages, Hospital, Long-term Care, Narrative Review, Older Adults, Physical Activity, Senior Health